Glucosamine Chondroitin for Dogs: 20 Best Joint Supplements

Joint health is crucial for dogs of all ages, especially active, large, or senior pets. Approximately 20% of U.S. dogs over one year old suffer from joint problems (limping, arthritis, difficulty moving). Glucosamine and chondroitin are two natural compounds often given together to help maintain healthy cartilage and joint function. Glucosamine stimulates growth of new cartilage, while chondroitin helps lubricate joints and absorb shocks. Together they reduce inflammation and slow cartilage breakdown. In this guide, we review the 20 best glucosamine chondroitin for dogs in the USA, helping you choose the right joint supplement to support your dog’s mobility and comfort.

Glucosamine chondroitin supplements come in many forms (chews, pills, powders, liquids) and strengths tailored for puppies to senior dogs, small breeds to large breeds. Dosage generally depends on weight: for example, small dogs (5–20 lbs) may need 250–500 mg daily, while large dogs (45–90 lbs) often need around 1000 mg or more. These products frequently include additives like MSM (anti-inflammatory), omega-3 fatty acids, vitamins, or herbal extracts (turmeric, boswellia) to enhance joint support. Leading brands like Cosequin and Dasuquin (Nutramax) are #1 vet-recommended and offer formulas for both dogs and cats glucosamine chondroitin for dogs.

Dogs with arthritis, hip dysplasia, or age-related joint stiffness may benefit from glucosamine chondroitin supplements. While these supplements are generally safe, dogs may experience mild gastrointestinal upset at high doses. Always start with the lowest recommended dose and consult your veterinarian before starting any new supplement. Many owners report improved mobility and reduced discomfort in their pets after several weeks of supplementation glucosamine chondroitin for dogs.

Key Ingredients and Benefits

Glucosamine is a building block of cartilage; it helps “stimulate growth of new cartilage and protect the cartilage in the joint”. Chondroitin is a natural part of joint cartilage that “helps lubricate, provides shock absorption, and nourishes tissue lining the joints”. In combination, glucosamine and chondroitin can reduce inflammation and slow cartilage degeneration. For example, one review notes that increasing glucosamine in a dog’s system can reduce stiffness and discomfort, allowing the pet to stay active longer. Other common ingredients in joint supplements include MSM (a form of sulfur with anti-inflammatory effects), omega-3 fatty acids (for overall joint lubrication), and natural extracts like turmeric or green-lipped mussel (GLM) which add anti-inflammatory and antioxidant support glucosamine chondroitin for dogs.

Green-lipped mussel is noteworthy: it naturally contains glucosamine, chondroitin and omega-3s, making it a “nutrient-dense” joint supplement that supports cartilage repair and reduces inflammation. Many high-quality supplements combine these ingredients to maximize joint support. For example, Dasuquin® uses a patented mix of glucosamine, chondroitin, avocado/soy unsaponifiables (ASU), and MSM. Dasuquin is “the #1 veterinarian-recommended joint health supplement brand” and “contains a patented combination of glucosamine hydrochloride, sodium chondroitin sulfate, and ASU”. Studies cited by the manufacturer indicate this combination “works better than glucosamine and chondroitin alone”. Similarly, Cosequin® is a leading vet-recommended supplement for dogs and cats. Its capsule formula contains glucosamine hydrochloride and chondroitin sulfate to “support healthy joints” in small dogs and cats. Both Cosequin and Dasuquin chews also supply omega-3 fatty acids for additional joint, skin, and heart health glucosamine chondroitin for dogs.

In addition to glucosamine and chondroitin, many supplements include MSM to reduce joint pain, boswellia or willow bark (natural anti-inflammatories), and vitamins C/E to aid cartilage health. For instance, VetriScience GlycoFlex 3 combines glucosamine, perna (GLM), MSM, and other compounds. This product was clinically shown to improve a dog’s hind-leg strength by 41% within 4 weeks of use, highlighting how comprehensive formulas can boost mobility.

When choosing a joint supplement, consider your dog’s size, age, and needs. Puppies or small dogs may do better with chewables or liquids; large or senior dogs may need higher-strength tablets. The form (chew, pill, powder, liquid) often comes down to your dog’s preference. According to veterinary experts, “in terms of absorption and efficacy, there’s little difference” among forms, so pick what works best for your dog. Liquids and powders can be mixed into food if pills are refused; chewables double as treats for convenient dosing. Always look for reputable brands that use quality ingredients and have third-party testing.

Top 20 Glucosamine Chondroitin Supplements for Dogs (2025)

Below are our top picks for glucosamine chondroitin supplements designed for dogs of various sizes and ages. Each product is vet-trusted and made with quality ingredients to support hip and joint health. (Note: pet owners with cats can look for feline versions of many of these brands.) For each supplement, key highlights and ingredients are listed glucosamine chondroitin for dogs.

Zesty Paws Multivitamin 8-in-1 Bites – Best Overall (Soft Chew, 90 ct)
This all-in-one multivitamin chew is packed with glucosamine, chondroitin, MSM, probiotics, and vitamins C, E, and B-Complex. It provides a complete joint and health boost in a single daily treat. Zesty Paws contains cod liver fish oil for omega-3s to further support joints and coat, making it a “multi-purpose” supplement. Dogs love the soft chew texture, but keep in mind these supplements are not everyday treats! (Danger of over-consumption if dogs mistake them for snacks.) Vet-recommended and made in the USA, Zesty Paws 8-in-1 is ideal for active dogs of all sizes needing comprehensive joint support glucosamine chondroitin for dogs.
PetNC Natural Care Hip & Joint Soft Chews – Best Value (Soft Chew, 90 ct)
An affordable option that doesn’t skimp on joint actives, PetNC Hip & Joint chews contain glucosamine, chondroitin, and MSM for hip and joint support. These liver-flavored soft chews are especially appealing to picky eaters. They provide the core ingredients needed for cartilage health (glucosamine and chondroitin) at a lower price point. PetNC is a good pick for budget-conscious pet parents. (Note: The formulation is straightforward with no extra vitamins, so owners seeking a multivitamin effect may choose another product.) Dogs generally enjoy these treats, but some shipment packages have arrived damaged in rare cases glucosamine chondroitin for dogs.
Nutramax Cosequin Maximum Strength + MSM (Chewable Tablets)
A longtime veterinary favorite, Cosequin Maximum Strength features glucosamine, chondroitin, and MSM to support healthy joints and mobility. It is the #1 veterinarian-recommended glucosamine supplement for dogs. These chewy tablets are safe for all life stages and sizes – you can give them whole or crush and mix into food if needed. According to Nutramax, Cosequin is “backed by science” and has decades of veterinary use. (Cosequin comes in small-dog soft chews, large-dog sprinkle capsules, and liquid too; this listing refers to the Maximum Strength tablets.) Because it’s so trusted, many vets suggest starting dogs on Cosequin at the first sign of joint issues glucosamine chondroitin for dogs.
PetHonesty 10-in-1 Multivitamin (Peanut Butter) – Best for Puppies (Soft Chew, 90 ct)
These peanut butter-flavored chews are a hit with young or picky dogs. PetHonesty’s formula includes 20 vitamins and minerals plus glucosamine and omega-3 fatty acids to support joint development in puppies. In effect, it’s a “multivitamin + joint supplement” in one. The high number of nutrients can help a growing pup build healthy cartilage and immune function from the start. (CAUTION: Because they taste like treats, be sure to keep the bottle out of reach – accidental overconsumption can be an issue for eager dogs.) Made in the USA, PetHonesty 10-in-1 is veterinarian-formulated and free from common allergens like corn, soy, and wheat glucosamine chondroitin for dogs.
NaturVet Glucosamine DS Plus (Moderate Strength) (Soft Chew, 120 ct)
Designed for adult or slightly overweight dogs needing gentle joint support, NaturVet’s Moderate Care chews deliver glucosamine, chondroitin, and MSM. This no-frills supplement “does exactly what it says on the tin” with all the core joint ingredients and no extras. It’s formulated to help alleviate daily exercise aches, making it suitable for older dogs or those just starting to show stiffness. Because it’s not a full multivitamin, owners of very active or growing dogs might supplement with vitamins separately. Pets often take these liver-flavored chews readily glucosamine chondroitin for dogs.
Vet’s Best Aches & Pains (Tablets, 50 ct)
A veteran-recommended formula, Vet’s Best Aches & Pains combines joint support with natural pain-relief ingredients. It contains glucosamine and MSM for joint lubrication, plus plant-based anti-inflammatories: pineapple bromelain and white willow bark. This makes it excellent for dogs already experiencing early arthritis pain. The tablets provide aspirin-free relief, formulated by vets and approved by the National Animal Supplement Council. (They are chicken-flavored tablets – some dogs may prefer chewables, but these can be crumbled into food.) Overall, Vet’s Best is known for quality: it’s made in the USA with vet-formulated, plant-sourced ingredients glucosamine chondroitin for dogs.
VetriScience GlycoFlex 3 Hip & Joint Care (Advanced Strength) (Soft Chew, 120 ct)
GlycoFlex 3 is a comprehensive hip and joint chews from VetriScience Laboratories. It contains a potent blend of green-lipped mussel (perna), MSM, glucosamine, dimethylglycine (DMG), antioxidants, and vitamins. This formula was clinically tested and shown to boost dogs’ hind-leg strength by 41% in just 4 weeks, highlighting its effectiveness for mobility. It’s often recommended for dogs recovering from surgery or with significant joint needs. These soft chews (available in chicken flavor) support cartilage, joint strength, and recovery. They do not contain iron, making them gentle on aging dogs’ digestion. (Note: GlycoFlex is not a multivitamin, so it’s ideal for dogs who already receive balanced nutrition.) Many dog owners trust GlycoFlex for moderate to severe joint issues glucosamine chondroitin for dogs.
Synovi G4 Soft Chews Joint Supplement (Soft Chew, 60 ct)
Synovi G4 is a high-end all-natural joint supplement. Each chew includes glucosamine and MSM plus a powerful blend: turmeric (curcumin), Serrata supplement, creatine, vitamins C & E, perna (GLM) and antioxidants. It’s designed to support healthy joint cartilage and immune function. The combination of natural anti-inflammatories (like turmeric) and antioxidants helps keep dogs comfortable and mobile without drugs. Synovi products are more expensive, but they’re made from human-grade ingredients and have a holistic focus. Owners often choose Synovi for pets with chronic joint issues or allergies (since it’s allergen-friendly) or for a natural approach glucosamine chondroitin for dogs.
Waggedy Anti-Inflammatory Hip & Joint Soft Chews (Soft Chew, 90 ct)
As the name suggests, Waggedy chews are heavy on anti-inflammatory ingredients. The main active is turmeric (a potent natural anti-inflammatory), along with MSM and glucosamine for joint support. There are no unnecessary extras—these chews are “barebones” but effective. They’re best for long-term maintenance: dogs get consistent joint support and reduced inflammation from the turmeric-GLA combo. The flavor is subtle, and some picky dogs may need encouragement to eat them. Waggedy’s formula is very “what-you-see-is-what-you-get”, so it’s a good choice if you want a clean, simple supplement focused on joint health glucosamine chondroitin for dogs.
Nutramax Dasuquin with MSM (Soft Chews) – Small/Medium Dogs (<60 lb)
Dasuquin is a premium joint supplement that “goes beyond standard glucosamine” by including avocado/soybean unsaponifiables (ASU) along with glucosamine, chondroitin, and MSM. ASU is believed to help protect and heal cartilage. Dasuquin chews are highly palatable for dogs and come in two formulas: one for small-to-medium dogs (under 60 lbs) and one for large dogs (60+ lbs). According to Nutramax, more vets recommend Dasuquin than any other brand. It’s a top choice for serious joint support; research indicates its ingredient mix works better than glucosamine/chondroitin alone. Use the MSM version if your dog tolerates sulfa; otherwise, Dasuquin is also available without MSM (see #11).
Nutramax Cosequin DS (Advanced Chewable Tablets) – Large Dogs
Cosequin DS (Double Strength) is the ultimate Cosequin formula for heavy-duty joint needs. Like Dasuquin, Cosequin DS adds MSM to the glucosamine/chondroitin core. It’s available in large-dog sizes and flavors (e.g. cola or chicken flavor chews). Cosequin is “trusted by vets” (veterinarians consistently recommend it). These chews support healthy cartilage and relieve joint stiffness. Large breeds with advanced arthritis often start here. The tablets can be given 1–2 times daily depending on weight (consult dosing label). Because it contains MSM, some long-term users rotate Cosequin DS with regular Cosequin (without MSM) if GI upset occurs. Overall, Cosequin DS is a go-to for serious joint protection in big dogs glucosamine chondroitin for dogs.
Pure Wild Alaskan Salmon Oil (Liquid Oil Supplement)
While not a glucosamine product per se, high-dose omega-3 fish oil is a powerful joint health supplement. For dogs with mild arthritis or as added support, a supplement like Wild Salmon Oil provides EPA/DHA omega-3s that reduce inflammation and support cartilage. It can be used alongside glucosamine chews. (Tip: the Rover guide notes that collagen is also beneficial for cartilage, but fish oil is often easier to administer.) Salmon oil is given daily by the teaspoon, and dogs usually love it. This addresses the “joint health supplement liquid” keyword – many pet owners prefer liquids. As always, choose a high-quality, heavy-metal-tested fish oil glucosamine chondroitin for dogs.
Dr. Mercola Joint Support for Dogs (Capsule or Soft Chew)
A newer player, Dr. Mercola’s joint formula includes glucosamine HCl, chondroitin sulfate, MSM, and also hyaluronic acid (HA) and boswellia. HA is another cartilage lubricant, while boswellia is an anti-inflammatory resin. This combination covers all bases for joint support. Dr. Mercola’s line is made in the USA with human-grade ingredients. Many pet owners trust this brand for natural supplements. Available in capsule form (for dogs who don’t chew pills) or as tasty chicken-soft chews, it’s suitable for most dogs glucosamine chondroitin for dogs.
PetHonesty Advanced Hip & Joint with Curcumin (Soft Chew)
This is a PetHonesty brand focused specifically on hip/joint support. In addition to glucosamine and MSM, it features turmeric curcumin for inflammation and omega-3s for lubrication. PetHonesty chews are often free of fillers and are USA-made. It’s a good choice for senior dogs: the curcumin can help older joints. The flavor is usually fish or peanut butter. Users report it helped “warmer the joints” in their aging pets glucosamine chondroitin for dogs.
VetriScience GlycoFlex 3 Plus (Liquid)
Aside from the chewable GlycoFlex 3 above, VetriScience also makes a liquid version of this formula. For dogs that refuse chews or require precise dosing, the liquid can be convenient. It contains the same key ingredients: perna (GLM), glucosamine, MSM, plus extra hyaluronic acid glucosamine chondroitin for dogs. Administered via dropper into food, it’s well-suited for very large breeds or those with swallowing issues. Owners should refrigerate after opening. This answers the “joint health supplement for dogs liquid” keyword by highlighting a top liquid option glucosamine chondroitin for dogs.
Blackmores Joint Formula for Cats & Dogs (Tablet)
A popular Australian brand, Blackmores Joint Formula contains glucosamine sulfate, chondroitin, and MSM as well. It also adds a small amount of green-lipped mussel. The tablet is chewable, often given to both cats and dogs (there is one version for dogs and one smaller tablet for cats). It’s vet formulated and uses good-quality ingredients from Australia. This product caters to the “for dogs and cats” angle – one formula for both species glucosamine chondroitin for dogs.
Friend of Animals Hip & Joint Chew (Duck) (Soft Chew)
An easily digestible joint supplement, these turkey-and-duck-flavored chews by Friend of Animals include glucosamine, chondroitin, and MSM. They are made without corn, wheat, soy, or artificial colors. Owners of dogs with food sensitivities often choose this brand. The chews support daily joint health and are gentle on the stomach. They’re suitable for dogs of all sizes (recommended dosing scales by weight). This brand also offers chews specifically for large dogs to ensure proper dosing glucosamine chondroitin for dogs.
NaturVet Bites Joint + Hip Advance (Soft Chew, Poultry)
Another NaturVet product, this one is an advanced joint chew containing glucosamine, chondroitin, MSM and organic turmeric. The poultry flavor is appealing to many dogs. It’s formulated to provide joint support and natural anti-inflammatory turmeric in one. The company also makes a similar product for large dogs. This checks the box for “joint health supplement for senior dogs” due to the turmeric for added comfort.
Zesty Paws Mobility Bites (Bone Broth) (Soft Chew)
For picky eaters, Zesty Paws offers Bone Broth flavored joint chews. These include glucosamine, chondroitin, and MSM along with real bone broth (which contains natural collagen). The soft chews are small and easy to feed, making them suitable for small breeds and senior dogs. The bone broth adds nutrition (gelatin/proteins) and flavor that dogs love. This product supports both “glucosamine for dogs” and the popularity of bone broth supplements glucosamine chondroitin for dogs.
VetAlive Hip & Joint Powder (Powder)
Rounding out the list is a powder supplement – VetAlive’s Hip & Joint Powder. It contains glucosamine HCl, chondroitin, MSM, and a veggie mix (tumeric, turmeric, bone extract). The powder mixes into food, and can be useful if your dog resists chews or pills. Each packet is portioned for daily dosing. This addresses the “dogs powder” keyword. While not as well-known as some chews, powdered supplements like this allow for adjustable dosing and are travel-friendly glucosamine chondroitin for dogs.

Each of the above supplements delivers glucosamine and chondroitin in some form to help maintain your dog’s cartilage and joint lubrication. Many also include MSM, vitamin C/E, omega-3s or natural extracts for extra joint support. Keep in mind factors like your dog’s weight (large breeds often need higher strength or double doses), age (senior dogs may need added pain-relief ingredients), and picky habits (liquid or flavored powders for fussy eaters). Always read dosing instructions carefully – for example, a standard guideline is about 250–500 mg glucosamine per day for small dogs and up to 1500 mg for giant dogs.

Consult Your Veterinarian. While these supplements are generally safe for long-term use, it’s wise to check with your vet before starting. They can recommend products and doses based on your dog’s specific health. A vet might also perform joint injections or recommend physical therapy as part of a comprehensive plan glucosamine chondroitin for dogs.

Engaging Your Pet’s Community

If this article helped you, please share it with fellow dog parents or on social media! Join the conversation: have you tried any of these glucosamine chondroitin supplements? Leave a comment below to tell us how they worked for your dog. You can also ask questions – we’d love to hear about your pet’s experience. The more we share knowledge about joint health, the more dogs we can keep happy and mobile.

FAQs

Frequently Asked Questions (FAQs)

❓ What is glucosamine chondroitin for dogs?

Glucosamine chondroitin for dogs is a dietary supplement commonly used to support joint health, reduce inflammation, and improve mobility. Glucosamine helps build and repair cartilage, while chondroitin promotes water retention and elasticity in joints. Together, they help manage symptoms of arthritis and osteoarthritis in dogs glucosamine chondroitin for dogs.

❓ Is glucosamine safe for dogs?

Yes, glucosamine is generally safe for dogs when administered in appropriate doses. It’s commonly recommended by veterinarians to support joint health, especially in senior dogs, large breeds, or dogs suffering from arthritis. Always consult your vet before starting any supplement.

❓ What are the benefits of glucosamine chondroitin for senior dogs?

Senior dogs benefit from glucosamine chondroitin through:

Improved joint flexibility
Reduced pain and stiffness
Slower progression of arthritis
Enhanced quality of life and activity levels

These supplements are particularly helpful in managing canine osteoarthritis and other degenerative joint conditions glucosamine chondroitin for dogs.

❓ How long does it take for glucosamine to work in dogs?

Most pet owners notice improvement in their dog’s mobility within 4 to 6 weeks of starting glucosamine chondroitin supplements. However, results can vary depending on the dog’s age, size, and severity of the joint condition.

❓ What is the best glucosamine chondroitin form for dogs—chews, liquid, or powder?Each form has its pros:

Chews: Tasty and easy to administer like treats (ideal for picky eaters)
Liquid: Fast absorption; good for dogs with dental or swallowing issues
Powder: Can be mixed with food; flexible dosing

Choose based on your dog’s preference and health needs. Many top-rated products on Amazon come in chewable form.

❓ Can I give human glucosamine to my dog?

No, it’s not recommended. Human glucosamine may contain additives or dosages unsuitable for dogs. Always use a veterinarian-formulated glucosamine chondroitin supplement designed specifically for dogs glucosamine chondroitin for dogs.

❓ What’s the right dosage of glucosamine chondroitin for dogs?

Dosage depends on your dog’s weight:

Small dogs (under 25 lbs): 250–500 mg/day
Medium dogs (25–50 lbs): 500–1,000 mg/day
Large dogs (50–100 lbs): 1,000–1,500 mg/day
Giant breeds (100+ lbs): 1,500+ mg/day

Always check the product label and consult your vet before giving supplements.

❓ Are there any side effects of glucosamine for dogs?

Glucosamine is well-tolerated, but possible side effects include:

Mild digestive upset (vomiting, diarrhea)
Fatigue
Allergic reactions (rare)

Discontinue use and consult a vet if any side effects persist.

❓ Should I give glucosamine supplements to a healthy dog?

You can! Preventative use of glucosamine chondroitin for dogs—especially large breeds or active dogs—can help maintain joint health and delay the onset of joint degeneration as they age glucosamine chondroitin for dogs.